Stemcell Therapy Technology News

Stem cells have yet to make it into mainstream civilian medicine, but that hasn't stopped the US military betting on them to save its personnel if there's a nuclear explosion or radiological attack.

On 3 January, the Department of Defense awarded a contract to two biotech firms to develop a treatment for radiation sickness based on stem cells extracted from the bone marrow of healthy adult donors. If the treatment, known as Prochymal, wins approval from the Food and Drug Administration, the Pentagon will purchase up to 20,000 doses at a total cost - including funding for development - of $224.7 million.

High doses of radiation kill by damaging the DNA of fast-dividing cells in the gut and bone marrow. If victims survive the diarrhoea, intestinal bleeding and loss of water caused by damage to their gut linings, they may succumb to fatal infections in the following weeks as ...

continune at:http://www.newscientist.com/article/mg19726383.200-us-funds-stemcell-therapy-for-radiation-sickness.html

Cancer stem cells might hold clue to melanoma growth

Globe Staff / January 17, 2008

In a key step from theory to possible treatment for melanoma patients, scientists in Boston report today that they were able to beat back a deadly human skin cancer in mice by targeting and destroying stem cells in the tumors.

The findings on malignant melanoma add weight to the growing belief among scientists that many types of cancer recur after treatment because small, resilient groups of stem cells survive and start multiplying again.

The research, published in tomorrow's journal Nature, shows that attacking melanoma stem cells is enough to halt a tumor's growth, said Dr. Markus Frank of Children's Hospital Boston, senior author on the paper. It thus offers new hope that this strategy will also work in humans - perhaps, researchers say, within just a few years.

"If this works with melanoma, this may also work with other tumors that are notoriously difficult to treat" once they have spread, said Dr. George Murphy, an author of the paper and chief of skin pathology at Brigham and Women's Hospital.

For more than a decade, scientists have been researching the theory that stem cells might be the worst villains in cancer, and the work has gathered momentum as stem cell populations have been discovered in cancers ranging from brain tumors to leukemia. Under a microscope, stem cells look like other cancer cells, but they can drive the growth of cancerous tumors in much the same way that normal stem cells can regenerate the body's healthy tissues

The paper is exciting and well done, said Dr. Peter Dirks, researcher of stem cells and brain tumors at the University of Toronto who was not involved in the work.

He cautioned, however, that this latest study, as well as others on cancer stem cells, are only preliminary, and it remains to be seen how broadly applicable the results are. Also, much of the work still awaits replication by other labs, he said.

"It's relatively early stages," he said, though he says he understands why the whole idea of cancer stem cells has recently "hit prime time: Because if you could treat those cells, maybe we'd have more effective, more long-lasting, more definitive cures for cancer. This [new] study is definitely a step in that direction."

One other concern that must be addressed with future research: whether killing the cancer stem cells brings with it "unexpected toxicity," hurting normal cells that use the same protein, said John E. Dick, also at the University of Toronto.

The study, whose first author was Tobias Schatton, focused on a protein lying on the surface of melanoma stem cells called ABCB5. Frank and his team, including his wife, Natasha Frank, had already shown that ABCB5 was a telltale marker for cells that could resist chemotherapy.

They set out to see whether melanoma cells that test positive for ABCB5 not only resist attack from treatments such as chemotherapy, but also serve as the seeds that then develop into more cancer.

What would happen, they wondered, if those nefarious cells were knocked out? Using monoclonal antibodies - molecular weapons that can hit highly specific targets - they went after the ABCB5-positive cells in human melanoma tumors grafted onto mice.

Tumor growth was "significantly inhibited," they report. Only three out of 11 mice developed new tumors, compared with 28 out of 28 mice whose cancer stem cells were left alone.

ABCB5 is actually a molecule that helps stem cells get rid of toxins - such as chemotherapy drugs - and thus helps tumors survive, Murphy said. "It's the very molecule that helps protect them that we have used to identify them."

Even if further experiments continue to look promising, it will likely be at least two or three years before the stem-cell strategy could start being tested in humans with melanoma, Frank said. But his lab will immediately try to develop the best possible antibodies for attacking melanoma stem cells, and will also use their findings to try to understand more about the biology of cancer stem cells, he said.

Malignant melanoma is the deadliest form of skin cancer, but it is easily treatable if caught early. Once it spreads, the disease is usually fatal. It kills an estimated 8,000 Americans per year out of a total 60,000 diagnosed.

Article From:http://www.boston.com/news/nation/articles/2008/01/17/cancer_stem_cells_might_hold_clue_to_melanoma_growth/

Joe C Mathew / New Delhi January 16, 2008
HEALTH: Reliance, Lifecell and , have emerged leaders in the stem cell banking sector.
It was a keen desire to secure the future of his soon-to-be born baby that made Japin Sibal, a young IT professional from Gurgaon, do an Internet search for various savings schemes available before him.
Weeks after, he zeroed in on one option — which was suggested to him by a friend and reinforced by his online enquiry — to bank his child’s cord blood stem cell.
Across metros and major towns of India, hundreds of young parents are doing what Sibal has done — to harvest and preserve their child’s cord blood for possible use in stem cell therapies for the baby or its immediate relatives. With 25 million births happening annually, stem cell banking in India offers great growth potential.
“I decided to go for stem cell banking for my child as I was confident of its usefulness. I found a lot of material on the Internet that suggested possible therapeutic opportunities using cord blood stem cells. Even our doctor suggested to go ahead,” Sibal says.
Seizing the opportunity, entrepreneurs — ranging from India’s biggest corporate player Reliance to a local NGO — are making early investments in setting up umbilical cord blood banks across the country.
While Reliance, Lifecell and Cryobank have already established a national footprint in cord blood stem cell banking, regional players are seeing this as a futuristic business option.
Leading the race is Chennai’s Lifecell, which is known to have harvested over 10,000 units of such stem cells through its 20 regional centres in the last two years.
The company, which holds an accreditation from the American Association of Blood Banks (AABB) for its facility, charges around Rs 70,000 for preserving each unit of cord blood component for a period of 21 years.
“Parents banking their baby’s umbilical cord blood stem cells with an AABB-accredited bank can be assured that the blood sample has been qualified, collected, tested, processed, and stored according to internationally approved and recognised standards. Moreover, this accreditation allows access to the banked cord blood from any part of the world, when needed,” Arasan, CEO, Lifecell, says.
Reliance Life Sciences (RLS), which offers stem cell banking services under the “Reli Cord” brand, is also in the process of getting a similar accreditation. RLS is known to have direct presence in at least 30 locations from where cord blood stem cells are harvested.
Cryobanks International India, a joint venture of Cryobanks of the United States and India’s largest franchise bottler RK Jaipuria Group, is the latest entrant having a national presence. Gurgaon-based Cryobanks, which started operations 18 months ago, has already managed to collect 1,500 units.
The company, which also operates in 30 cities, is looking at harvesting at least 5,000 units during 2008. While the prices offered by all three are the same, Cryobanks has introduced installment schemes. Sibal, for instance, opted for a five-year installment programme.
“We are in the process of signing contracts with some IT majors to introduce company-sponsored stem cell harvesting programmes for their employees. The employee with have to bear only 50 per cent of the expenses as the balance will be paid by the employer,” Aasim Ghazi, head (marketing), Cryobanks, says.
Interestingly, Cryobanks has tied up with the RK Jaipuria Group and polyester major Indo Rama Group to set up a cord blood bank facility in Thailand.
The latest to foray into the sector is the Chennai-based not-for-profit organisation Jeevan Blood Bank and Research Centre. The move is significant because of the organisation’s stress on public stem cell banking over “private banking” as practiced by other players.
While all three existing players have a “public banking” concept, the majority of the cases handled by them today are from the “private banking” segment.
Jeevan attempts to promote “public banking”, which means harvesting and preservation of cord blood samples received through donations. While the “donor” will have no rights over the stem cells, the “recipient” will have to pay for the expenses incurred by Jeevan in preserving the cells.
“We plan to provide stem cells for free to poor patients and charge Rs one lakh from the rich as cross subsidy,” P Srinivasan, chairman, Jeevan Blood Bank and Research Centre, says.
According to him, not many players will venture into “public banking” because it involves huge investment and a high maintenance cost.
Even though stem cell banking has started to pick up, the centres that could make use of these cells and offer treatments are few in number.
However, Lifecell offers solution for that problem. In November 2007, it announced the setting up of Tricell, its therapeutic unit attached to Ramachandra Medical University, Chennai.
“While Lifecell will go ahead with stem cell banking business, Tricell will offer the treatment,” a company spokesperson says.
According to a government official, stem cell banking will become a public health priority only after its benefits are proved.
“Of the 75 type of diseases that have been approved for stem cell research, only a handful are a proven success. Unless it becomes a necessity for masses, government initiatives may not happen,” he says.
The industry seems to be hopeful. So are the NGOs, and the patients.

Artilce From :http://www.business-standard.com/common/storypage.php?autono=310816&leftnm=5&subLeft=0&chkFlg=

By John Connolly

ORLANDO, Florida, January 14, 2008 (LifeSiteNews.com) - Scientists have created a beating heart using laboratory techniques that involve adult stem cells and that could revolutionize organ donation.

Scientists at the University of Minnesota reported their findings at the American Heart Association's annual meeting in Orlando, Florida. The highly experimental procedure involved removing all the cells from a rat's dead heart, and using its protein blueprint as a guide for live adult stem cells seeded on the old heart.

"We took nature's building blocks to build a new organ," said Harald Ott, who worked on the project. "When we saw the first contractions we were speechless."

The ethical questions concerning heart donation could be completely sidestepped by such a process. Furthermore a new heart, grown in this way, would not be rejected by the patient's immune system, which is a common problem with organ transplants.

The procedure, however, is still in an experimental state, and it will probably be years before it can be tried on humans. Professor Doris Taylor, director of the University of Minnesota's center for cardiovascular repair, is very hopeful that this new breakthrough is a significant step towards the ability to create custom-built hearts as well as other organs.

"The idea would be to develop transplantable blood vessels or whole organs that are made from your own cells," Taylor said. "It opens a door to the notion that you can make any organ - kidney, liver or pancreas. You name it and we hope we can make it. This is a proof of concept. Going forward, our goal is to use a patient's stem cells to build a new heart."

Adult stem cells have led to many breakthroughs in medical science in recent years, in stark contrast to the lack of progress with ethically unacceptable embryonic stem cell research. Adult stem cells may be used to treat everything from heart attacks to damaged teeth. Many experimental projects have shown and are increasingly showing great promise for use of adult stem cells on human subjects.


Article From:http://www.lifesite.net/ldn/2008/jan/08011405.html

Singapore - Inspired by an orange juicer, two Singapore academics have invented a device that they claim can extract more stem cells from a placenta than current methods from the umbilical cord, a news report said Tuesday. Professor Ng Soon Chye and Associate Professor Tan Kok Kiong at the National University of Singapore told the Straits Times that three companies from the city-state, Japan and Britain are interested in the invention.

During a coffee break, the duo considered an orange juicer.

"We then had an idea: squeeze as much as possible, like the juicer," Ng was quoted as saying.

Their brainstorming resulted in the placenta "juicer," which presses down and squeezes on the placenta to extract as much cord blood as possible.

Stem cells can be extracted from the umbilical cord after birth and used to treat patients with blood diseases or used in bone-marrow transplants.

Some parents have their newborns' cord blood stored. The umbilical cord would otherwise be discarded.

Current extraction methods use a syringe to suck up as much blood as possible from the umbilical cord.

Ng and Tan said their device can exact as much as 10 times the amount of cord blood, or 10 times the amount of stem cells.

Original Article:http://www.earthtimes.org/articles/show/173562,placenta-juicer-developed-to-extract-more-stem-cells.html

INVESTMENT BANKER DONATES $20 MILLION

By Barbara Feder Ostrov
Mercury News
San Francisco investment banker John Scully and his wife, Regina, have donated $20 million to Stanford's medical school and hospital to help expand stem-cell research at the university, Stanford officials said Wednesday.

The money will go toward a new medical school building with laboratories for stem-cell and regenerative-medicine research. The university hopes to break ground on that building late this year. The donation also will be used to create space for stem-cell treatment of patients within a planned expansion of Stanford University Medical Center that is expected to be completed in 2015.

Scully, 63, said he was motivated to support stem-cell research because of its potential for treating diseases like cancer and because funding for such research has been severely limited by federal restrictions since 2001.

"I don't believe government should restrict scientific inquiry," said Scully, who graduated from Stanford's Graduate School of Business in 1968 and is managing director of SPO Partners & Co. in Mill Valley. "But . . . I'm highly confident those federal restrictions will go away. Perhaps gifts like mine will hasten that day by showing the potential for stem-cell therapies."

Stanford has been positioning
itself as a major player in stem-cell research. In March 2007, Business Wire founder Larry Lokey December donated $33 million to Stanford Medical School to promote stem-cell research. Then, last month, medical school researchers received nearly $11 million from the California Institute for Regenerative Medicine to help advance the careers of young scientists in the field.


Article:http://www.mercurynews.com/greenenergy/ci_7930193?nclick_check=1

TOKYO (AFP) — Stem cell technologies could be used to cure diseases and heal injuries within 10 years, a Japanese scientist who recently broke new ground in the field said Wednesday.

Shinya Yamanaka of Kyoto University, whose team reported in November they reprogrammed human skin cells to be indistinguishable from stem cells taken from human embryos, said the new technology is so simple that many laboratories are competing to make further breakthroughs.

Yamanaka, meeting reporters in Tokyo, said it was a matter of time before such stem cell technology was used in hospitals.

"I can tell for some patients and for some diseases it may be not, like, 10 years, but for some diseases I can imagine it can take longer than 10 years," Yamanaka said.

"That depends on diseases and injuries. There's no single answer," he said.

Stem cells are primitive cells that eventually turn into any of the 220 different types of cells in the human body.

Stem cells offer enormous potential for curing and treating disease because it is hoped they can replace damaged or diseased cells, tissues and organs.

But stem cell research has been highly controversial because -- until now -- viable embryos had to be destroyed to extract the stem cells.

The research by Yamanaka's team, who worked alongside US researchers led by James Thomson of the University of Wisconsin at Madison, was praised by the Roman Catholic Church and other critics of embryo research.

The research has since accelerated. Yamanaka said that up to five laboratories in the United States and several in Japan have since also produced stem cells from human skin, known as pluripotent stem cells, or iPS cells.

"This is because technology is very simple," he said. "All you need is a basic technology, cell biology" and "you don't need special technology or equipments."

Yamanaka said having lots of rivals in his research area has caused him a lot of stress but that he believes "it speeds up everything, the process, because of the competition."

"So I think it's very good for patients who are waiting" for treatment, he said.